A Timeline of Discovery and Current Research on Primary Open-Angle Glaucoma and Emergence of Potentially Permanent Treatment Solutions

This research examines the timeline of discovery and Primary Open-Angle Glaucoma (POAG). By reviewing literature on genetic molecular mechanisms, we aim to emphasize a long-term treatment solution (iSTENT) mitigate intraocular pressure (IOP) related POAG etiology disease progression. is multifactorial, autosomal dominant, adult-onset eye wherein optic nerve cells become damaged due buildup excess aqueous humor, resulting in increased IOP. Consequently, leads progressive loss peripheral vision leading cause blindness US. Due multifactorial nature glaucoma’s inheritance pattern pathology, over 20 disease-associated loci have been implicated with its mechanisms remain relatively obscure. remains hotbed for relationships between heterogeneity environmental/genetic factors. To develop more permanent Glaucoma, highlight surgical insertion stent trabecular meshwork providing long-lasting dilation blocked drainage channels IOP procedure would allow humor outflow from subsequent reduction pressure-induced retinal ganglion cell damage. POAG’s polygenic environmental factors currently experienced by 2.25 million Americans will continue grow as POAG-associated genes are maintained generations. Therefore, complete understanding history, etiology, critical development effective options.